Testolactonum [Inn-Latin]

Antineoplastic Agents, Hormonal

Testolactonum [Inn-Latin] Brand names, Testolactonum [Inn-Latin] Analogs

Testolactonum [Inn-Latin] Brand Names Mixture

No information avaliable

Testolactonum [Inn-Latin] Chemical_Formula

C₁₉H₂₄O₃

Testolactonum [Inn-Latin] RX_link

http://www.rxlist.com/cgi/generic2/testolactone.htm

Testolactonum [Inn-Latin] fda sheet

Testolactonum_[Inn-Latin] FDA

Testolactonum [Inn-Latin] msds (material safety sheet)

Testolactonum_[Inn-Latin] MSDS

Testolactonum [Inn-Latin] Synthesis Reference

No information avaliable

Testolactonum [Inn-Latin] Molecular Weight

300.392 g/mol

Testolactonum [Inn-Latin] Melting Point

218.5 ^oC

Testolactonum [Inn-Latin] H₂O Solubility

Slightly soluble (27.4 mg/L)

Testolactonum [Inn-Latin] State

Solid

Testolactonum [Inn-Latin] LogP

3.663

Testolactonum [Inn-Latin] Dosage Forms

For oral administration as tablets providing 50 mg testolactone per tablet

Testolactonum [Inn-Latin] Indication

For palliative treatment of advanced breast cancer in postmenopausal women.

Testolactonum [Inn-Latin] Pharmacology

Testolactone is a synthetic anti-neoplastic agent that is structurally distinct from the androgen steroid nucleus in possessing a six-membered lactone ring in place of the usual five-membered carbocyclic D-ring. Despite some similarity to testosterone, testolactone has no in vivo androgenic effect. No other hormonal effects have been reported in clinical studies in patients receiving testolactone.

Testolactonum [Inn-Latin] Absorption

Testolactone is well absorbed from the gastrointestinal tract.

Testolactonum [Inn-Latin] side effects and Toxicity

Oral LD₅₀s in mouse and dog are 1630 mg/kg and 593-926 mg/kg, respectively.

Testolactonum [Inn-Latin] Patient Information

Testolactonum [Inn-Latin] Organisms Affected

Humans and other mammals